Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | Set_03_absentNotch_versus_normalThy.phenotype_absentNotch_versus_normalThy.cls #absentNotch_versus_normalThy.phenotype_absentNotch_versus_normalThy.cls #absentNotch_versus_normalThy_repos |
| Phenotype | phenotype_absentNotch_versus_normalThy.cls#absentNotch_versus_normalThy_repos |
| Upregulated in class | absentNotch |
| GeneSet | HUMANCYC_SUPERPATHWAY OF HISTIDINE, PURINE, AND PYRIMIDINE BIOSYNTHESIS |
| Enrichment Score (ES) | 0.75959736 |
| Normalized Enrichment Score (NES) | 1.6704698 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.047336828 |
| FWER p-Value | 0.278 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | GUK1 | 5900059 | 59 | 5.970 | 0.0812 | Yes | ||
| 2 | NME2 | 2190672 | 173 | 4.687 | 0.1414 | Yes | ||
| 3 | CAD | 2340717 | 214 | 4.419 | 0.2017 | Yes | ||
| 4 | ADSL | 5570484 | 247 | 4.249 | 0.2600 | Yes | ||
| 5 | PPAT | 1980019 | 255 | 4.206 | 0.3191 | Yes | ||
| 6 | IMPDH2 | 5220138 | 294 | 4.012 | 0.3737 | Yes | ||
| 7 | NME1 | 770014 | 457 | 3.394 | 0.4130 | Yes | ||
| 8 | DHODH | 3170072 | 584 | 3.086 | 0.4498 | Yes | ||
| 9 | NME4 | 3140736 5900446 | 589 | 3.067 | 0.4929 | Yes | ||
| 10 | PAICS | 610142 | 608 | 3.017 | 0.5346 | Yes | ||
| 11 | GART | 5910114 7000594 | 812 | 2.592 | 0.5603 | Yes | ||
| 12 | CTPS | 70451 1740132 | 844 | 2.532 | 0.5944 | Yes | ||
| 13 | RRM1 | 4150433 | 892 | 2.462 | 0.6267 | Yes | ||
| 14 | UMPS | 2340541 4730438 | 1214 | 2.044 | 0.6383 | Yes | ||
| 15 | GMPS | 460670 | 1227 | 2.028 | 0.6663 | Yes | ||
| 16 | PRPSAP1 | 6980494 | 1366 | 1.853 | 0.6851 | Yes | ||
| 17 | AK2 | 4590458 4760195 6110097 | 1395 | 1.814 | 0.7092 | Yes | ||
| 18 | IMPDH1 | 3190735 7050546 | 1418 | 1.779 | 0.7332 | Yes | ||
| 19 | AK3L1 | 7100601 | 1503 | 1.676 | 0.7523 | Yes | ||
| 20 | PRPS1 | 6350129 | 1749 | 1.447 | 0.7596 | Yes | ||
| 21 | ADSSL1 | 4850132 7000288 | 3310 | 0.482 | 0.6825 | No | ||
| 22 | NME7 | 60170 1230551 2850333 4200102 4560411 5090647 | 3451 | 0.432 | 0.6810 | No | ||
| 23 | AK5 | 6290348 | 3484 | 0.421 | 0.6853 | No | ||
| 24 | NME6 | 510136 6380722 | 3893 | 0.301 | 0.6676 | No | ||
| 25 | RRM2B | 1690025 1690465 4010400 | 4287 | 0.224 | 0.6496 | No | ||
| 26 | PRPSAP2 | 60242 6590239 | 4918 | 0.143 | 0.6177 | No | ||
| 27 | PURA | 3870156 | 9881 | -0.001 | 0.3507 | No | ||
| 28 | AK1 | 130605 | 10683 | -0.013 | 0.3078 | No | ||
| 29 | CTPS2 | 360647 3940110 | 14517 | -0.169 | 0.1040 | No | ||
| 30 | RRM2 | 6350059 6940162 | 15607 | -0.475 | 0.0521 | No | ||
| 31 | ATIC | 4010593 6380463 | 15716 | -0.529 | 0.0537 | No | ||
| 32 | KIF13B | 2480451 3830368 | 16193 | -0.790 | 0.0393 | No | ||
| 33 | NME3 | 1660440 | 18529 | -6.441 | 0.0047 | No |
